FREE RADICAL SCAVAGING ACTIVITY AND ANTIDIABETIC PROPERTY OF ETHANOL STEM BARK EXTRACT OF Uapaca togoensis IN ALLOXAN INDUCED DIABETIC ALBINO RATS

Diabetes mellitus is a disease of worldwide significance and increasing prevalence. This places demand on researchers to find solution it through ethnomedicine. study investigated the toxicological, antioxidant, anti-diabetic property hyperlipidemic effect Uapaca togoensis stem bark extract in alloxan induced diabetic wistar rats. Thirty (30) albino rats were assigned into six groups (A-F) five each. Group A was not used as positive control/nondiabetic group, while B-F with at 150mg/kg administered via intraperitoneally (i.p). B control treated but allowed access feed water. C, D E 300mg/kg, 700mg/kg 1000mg/kg respectively; group F standard drug (glibenclimide) dose 5mg/kg. The doses orally treatment lasted for 7 days. Results indicated that have hypoglycemic activity Modified method Lorke employed ascertain toxicity result however safe test up 5000mg per body weight dose. DPPH, FRAP Hydrogen peroxide assays assess antioxidant activities extract. results significant p<0.05 all concentrations compared (vitamin C) % inhibitory almost same Vitamin C hydrogen method. an indication Uapacatogeonsis extractpossess properties.